Adipose Tissue Biology by Christian Dani, Nathalie Billon (auth.), Michael E. Symonds

By Christian Dani, Nathalie Billon (auth.), Michael E. Symonds (eds.)

This e-book is designed to supply a entire perception into present views and demanding situations in adipose tissue biology. In <i>Adipose Tissue Biology</i>, scientists and clinicians talk about adipocyte precursors, differentiation and progress, brown and white adipose tissue, gender, irritation, nutritional and genetic determinants of fats mass, including evolutionary and developmental elements of adiposity.

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Mol Cell Biol 27(21):7462–7474 Djian P, Roncari AK, Hollenberg CH (1983) Influence of anatomic site and age on the replication and differentiation of rat adipocyte precursors in culture. J Clin Invest 72:1200–1208 Dowell P, Flexner C, Kwiterovich PO et al (2000) Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors. J Biol Chem 275:41325–41332 Fajas L, Egler V, Reiter R et al (2002a) The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation.

Biochemistry 44:11098–11105 Xie H, Lim B, Lodish HF (2009) MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes 58(5):1050–1057 Yagi K, Kondo D, Okazaki Y et al (2004) A novel preadipocyte cell line established from mouse adult mature adipocytes. Biochem Biophys Res Commun 321:967–974 Yarmo MN, Landry A, Molgat AS et al (2009) Macrophage-conditioned medium inhibits differentiation-induced Rb phosphorylation in 3T3-L1 preadipocytes. Exp Cell Res 315:411–418 Yu C, Markan K, Temple KA et al (2005) The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor g transcriptional activity and repress 3T3L1 adipogenesis.

The miRNA expression profile of visceral and subcutaneous adipose tissue is different in obese and non-obese subjects (Ortega et al. 2010; Klöting et al. 2009). A genome-wide miRNA profiling study of 723 human miRNAs have disclosed the expression of 40 (in preadipocytes) and 31 (in adipocytes) mature miRNAs that significantly differed according to obese status. M. M. Fernández-Real tissue was also associated with parameters of adipose tissue physiology, glucose metabolism and obesity status. This study revealed that miRNAs may constitute biomarkers for obesity and obesity-related complications.

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