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Extra info for Advances in Applied Microbiology, Vol. 44
In this case, the metabolites contained 18 amino acid residues compared to 19 in the chrysospermins, so that belong to the recognized group of long-sequence peptaibols. Both groups contain similar residues at positions 4, 5, 9, 15, and 16. The trichorzins, which were isolated from two strains of T harzianum from soil collected in Uruguay and Malaysia, were produced in a defined medium containing glucose as the carbon and energy source and potassium nitrate as the nitrogen source, together with inorganic salts.
5 and 20 pA4 using ET, receptors and endothelin-1. In a screening program aimed at the discovery of interleukin-1 receptor binding antagonists, Kuo and colleagues (1995) found a PenicilIium patulum that produced bioactivity, and bioactivity-guided isolation led to the known compounds gentisyl alcohol and epiepoformin. , 1990). Mechanistically this approach probably works by removing feedback inhibition from metabolic pathways and by sequestering intermediates. 7 mM. VIII. Antiinfective Agents There is a chronic unmet need for new antifungal agents to be used clinically along with amphotericin and the azoles.
1996). The asterriquinones CT1-CT5 were specific inhibitors of certain serine proteases involved in blood coagulation. Factors VIIa, Xa/Va and Xa were inhibited, with ICs0 values between 3 and 135 yg/ml for those that were active, whereas thrombin and trypsin were very much less sensitive to these metabolites. Once blood clots have formed, the fibrinolytic system dissolves them over time. Plasmin, the primary degradation enzyme, is derived from plasminogen, which itself is activated by tissue-type activators, and this is accelerated on fibrin surfaces.
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